Abstract
Aim and Objective:
The main objective of this research was to formulate and evaluate gastroretentive-floating multiparticulate system of lisinopril to prolong the gastric residence time.
Materials and Methods:
Gastroretentive system of lisinopril was developed by ionotropic-gelation technique using isabgol (
Plantago ovata
F.) husk mucilage (IHM) as a floating agent, sodium alginate as a mucoadhesive polymer, and sodium bicarbonate as a gas-generating agent.
Results:
The beads were evaluated for entrapment efficiency (EE),
in vitro
drug release, and
ex vivo
mucoadhesion. The beads of batch F-2 exhibited high-EE (96.04 ± 0.74%), complete drug release (95.27 ± 0.12%), and good mucoadhesion (50% in 8 h). The
in vitro
drug release from these beads exhibited first-order kinetics that followed Higuchi diffusion model.
Conclusion:
The beads by virtue of the high EE, complete drug release, and good mucoadhesivity that exhibit prolonged gastric residence time are likely to improve the bioavailability of the drugs having the absorption window in proximal stomach.
Recommended Citation
Moganti, Manasa and Shivakumar, H. N.
(2017)
"Formulation and evaluation of gastroretentive-floating multiparticulate system of lisinopril,"
Indian Journal of Health Sciences and Biomedical Research KLEU: Vol. 10:
Iss.
1, Article 11.
DOI: https://doi.org/10.4103/2349-5006.198589
Available at:
https://kleijhsbr.researchcommons.org/journal/vol10/iss1/11
Pages
50
Last Page
56
Copyright
© 2017 Indian Journal of Health Sciences and Biomedical Research KLEU | Published by Wolters Kluwer – Medknow