Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer

Authors

Anjana Adhyapak, Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India
B. G. Desai, Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, Indi

Abstract

Background:

The current study assessed the effect of tamoxifen-loaded transdermal patch in Dimethylbenz(a)anthracene (DMBA)-induced breast cancer.

Materials and Methods:

Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, mannitol were formulated and were evaluated in DMBAinduced breast cancer in female albino Wistar rats. Multiple parameters such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT were evaluated.

Results:

Treatment with formulations showed a decrease in body weight contrast to disease. Equally, a considerable increase in hemoglobin was observed in the formulation treated group over disease grouping. Likewise, there decrease in SGPT and SGOT in formulation compared to disease.

Conclusion:

The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity.

Recommended Citation

Adhyapak, Anjana and Desai, B. G. (2020) "Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer," Indian Journal of Health Sciences and Biomedical Research KLEU: Vol. 13: Iss. 3, Article 9.
DOI: https://doi.org/10.4103/kleuhsj.kleuhsj_38_20
Available at: https://kleijhsbr.researchcommons.org/journal/vol13/iss3/9

Pages

230

Last Page

234

Copyright

© 2020 Indian Journal of Health Sciences and Biomedical Research KLEU | Published by Wolters Kluwer – Medknow