Prostate-Specific antigen An overview and its current status in the diagnosis of prostate cancer

Authors

Siddalingeshwar Neeli, Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, India
Manas Sharma, Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, India
Abhijit Musale, Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, India

Abstract

Prostate-Specific Antigen (PSA), which has high organ specificity and poor cancer specificity, has been widely utilized for the diagnosis and treatment of prostate cancer; though it is not an ideal tumor marker. Its extensive usage in screening programs has resulted in a large number of unwanted biopsies, over-diagnosis and over-treatment of indolent cancers as well. Hence, various PSA derivatives and PSA-based tests have evolved to improve the accuracy of prostate cancer diagnosis. This article provides an overview of PSA and PSA-based biomarkers and their current role in the screening and diagnosis of prostate cancer.

Recommended Citation

Neeli, Siddalingeshwar; Sharma, Manas; and Musale, Abhijit (2021) "Prostate-Specific antigen An overview and its current status in the diagnosis of prostate cancer," Indian Journal of Health Sciences and Biomedical Research KLEU: Vol. 14: Iss. 1, Article 4.
DOI: https://doi.org/10.4103/kleuhsj.kleuhsj_97_19
Available at: https://kleijhsbr.researchcommons.org/journal/vol14/iss1/4

Pages

22

Last Page

30

Copyright

© 2021 Indian Journal of Health Sciences and Biomedical Research KLEU | Published by Wolters Kluwer – Medknow