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Abstract

CONTEXT:

Denture relining materials are soft and resilient materials used in the treatment of patients with denture soreness. Studies have concluded that rugged surface of the liners allows the sticking of the

Candida albicans

and later gives rise to a condition called denture-induced stomatitis.

AIMS:

The aim of this study is to evaluate and compare the antifungal efficacy and potency of denture soft liners incorporated with powder extract of

Lawsonia inermis

and

Withania somnifera

on the growth of

C. albicans

.

MATERIALS AND METHODS:

A total of 105 samples were taken in this

in vitro

study and was divided into three groups: To check for the antifungal activity with 35 samples each.

L. inermis

and

W. somnifera

powder extract were incorporated in soft liner at 1%, 3%, 5%, and 7% concentration and the antifungal efficacy against

C. albicans

was tested by calculating the diameter of inhibition zone for 1, 7, and 14 days.

STATISTICAL ANALYSIS USED:

Subgroup analysis was carried out using one-way analysis of variance (ANOVA) test. Pair-wise comparisons were carried out through Tukey's multiple

post hoc

procedures.

RESULTS:

When comparison of four subgroups (1%, 3%, 5%, and 7%) was done with the mean zone of antifungal efficacy at 1

st

day, 7

th

day, and 14

th

day time points in both the groups by one-way ANOVA, statistically significant results were obtained with

P

of 0.0001.

CONCLUSIONS:

L. inermis

and

W. somnifera

natural herb extracts have shown to have antifungal activity against

C. albicans

and can be used as an alternative for the synthetic antifungal drugs.

Pages

54

Last Page

59

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