Abstract
Factor X is a Vitamin K-dependent serine protease synthesized in the liver. It is a key factor of the coagulation cascade as it is the first enzyme of a common pathway that leads to the formation of a stable fibrin clot. Both intrinsic and extrinsic pathways can lead to factor X activation. Inherited factor X deficiency is a rare autosomal recessive bleeding disorder. Inherited factor X deficiency is caused by mutations of the factor X gene that result in reduced or aberrant function of the factor X protein. Symptomatically, homozygous patients with severe hemorrhagic symptoms present early in the neonatal or childhood period, whereas symptomatic heterozygotes may bleed only after severe major surgery or trauma. Here, we present a case of neonate presented with bleeding manifestation. The clinical manifestation and hematological workup showed a severe factor X deficiency.
Recommended Citation
Patra, Arjani; Ansari, Qudsiya; Randad, Kailas G.; and Singh, Vinaya Ajaykumar
(2024)
"Neonatal presentation of factor X deficiency,"
Indian Journal of Health Sciences and Biomedical Research KLEU: Vol. 17:
Iss.
2, Article 15.
DOI: https://doi.org/10.4103/kleuhsj.kleuhsj_13_24
Available at:
https://kleijhsbr.researchcommons.org/journal/vol17/iss2/15
Pages
167
Last Page
169
Copyright
Copyright: © 2024 Indian Journal of Health Sciences and Biomedical Research KLEU
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