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Keywords

Animal models, Bone defects, Bone fill, Bone regeneration, Chitosan

Abstract

Chitosan-based biomaterials are biocompatible, biodegradable and can be formed into composites, scaffolds and hydrogels, making it an ideal candidate in the application of bone tissue engineering. Addition of growth factor, bioactive molecules and nanoparticles to chitosan promotes osteogenesis and angiogenesis, thereby enhancing bone repair. But further research is needed due to challenges like its limited mechanical strength and stability under physiological conditions. So, the focus question of this review was ``Is the use of chitosan-based biomaterials effective in promoting bone regeneration.'' Electronic literature review was conducted on Medline/PubMed, Embase, Web of Science databases, without any limitations on the year of search along with manual search. The literature search resulted in 119 published scientific papers. Final screening resulted in 53 studies included in this present review. The included studies showed that chitosan-based biomaterials demonstrated significant potential for use in alveolar bone regeneration due to their biocompatibility, biodegradability, and capacity to be modified into scaffolds, hydrogels, and composites. Their ability to enhance osteogenesis and angiogenesis, particularly when combined with growth factors and bioactive molecules, suggests promising applications in periodontal regeneration, alveolar bone repair, and implant-related procedures.

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5

Last Page

30

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