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Abstract

Introduction:

The word hydatidiform means drop of water and mole is a shapeless mass. It is an abnormal placenta having enlarged, edematous and vesicular chorionic villi accompanied by variable amount of proliferative trophoblast. It is of two types complete and partial. The diagnosis is based on clinical findings, biochemical markers like human chorionic gonadotropin (HCG) histopathology and genetics. The objective of this study was to determine the frequency, clinical presentation and significance of HCG and histopathology in the diagnosis of hydatidiform mole.

Materials and Methods:

Results were measured in terms of age of patients, gestational age, clinical details, investigations specially HCG, histopathology.

Results:

Totally 67 specimens were examined and diagnosed, which included 37 cases of complete and 30 cases of partial mole. The common age of patients with complete hydatidiform mole was above 35 years whereas 21-35 years with partial hydatiform mole. Most presenting complaint was bleed/vaginum.

Conclusion:

Complete mole was more frequent. Histopathological examination along with clinical findings and HCG is mandatory to differentiate Complete and Partial Mole. The clinical findings may overlap due to earlier removal of hydatiform mole before the clinical symptoms develop even after expulsion of the fetus both of which may result in a false diagnosis. We concluded that there is no single criterion to differentiate Complete from partial mole. P57kip2 expression will complement histopathological evaluation in the diagnosis of difficult cases.

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