Abstract
Acute promyelocytic leukemia (APL) has defined biology and clinical course that is, distinct from the other forms of acute myelogenous leukemia. It may present with potentially devastating coagulopathy and the sensitivity to retinoid differentiating agents, including all-trans retinoic acid and arsenic trioxide, hence a fast and definite diagnosis is imperative. Reciprocal 15, 17 translocation creates a
PML/RARA
fusion gene on the derivative chromosome 15, which can be detected by various molecular tests such as cytogenetics, fluroscence
in-situ
hybridization (FISH), reverse transcriptase-polymerase chain reaction. We present here a diagnostically challenging case, both morphologically and immunophenotypically proven to be APL, which was negative for the
PML/RARA
by FISH.
Recommended Citation
Mundada, Manasi Chetan; Ahmed, Faiq; Devi, G. S.; Murthy, Sudha; and Mohan, M. V. T.
(2015)
"Fluroscence A cryptic puzzle,"
Indian Journal of Health Sciences and Biomedical Research KLEU: Vol. 8:
Iss.
1, Article 12.
DOI: https://doi.org/10.4103/2349-5006.158238
Available at:
https://kleijhsbr.researchcommons.org/journal/vol8/iss1/12
Pages
60
Last Page
63
Copyright
© 2015 Indian Journal of Health Sciences and Biomedical Research KLEU | Published by Wolters Kluwer – Medknow