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Abstract

Background:

Methanolic extract of

Napoleona imperialis

, was evaluated for anti-inflammatory effect.

Method:

Inflammogens used were carrageenan, histamine and formaldehyde.

Napoleona imperialis

(200-600mg/kg) was administered orally 30 minutes before the induction of inflammation. Diclofenac (10-100mg/kg) and chlorpheniramine (10-100 mg/kg) was administered intraperitoneally.

Results:

Extract and Diclofenac significantly (F

4, 12

=15.55,

P

<0.01; F

4, 12

=13.76

P

<0.01, respectively) inhibited inflammation induced with carrageenan, with extract's maximal inhibitory effect of 64% at dose 400 mg/kg. Diclofenac showed maximal inhibitory effect of 67% at dose 30 mg/kg. Extract and chlorpheniramine significantly (F

4, 12

=22.14,

P

<0.01; F

4, 12

=16.81,

P

<0.001, respectively) reduced histamine-induced edema with extract having maximal inhibitory effect of 73% at 200 mg/kg. Chlorpheniramine also had maximal inhibitory effect of 70% at 10 mg/kg. Extract and diclofenac significantly (F

3, 16

=11.06

P

<0.001; F

3, 16

=22.4

P

<0.0001, respectively) reduced acute phase of the formaldehyde-induced arthritis. Extract produced maximal effect of 67% at 200 and 400 mg/kg. Diclofenac had a maximal effect of 85% at 100 mg/kg. The chronic phase was ameliorated by extract and diclofenac significantly (F

3, 16

=11.18

P

<0.001; F

3, 16

=18.07

P

<0.0001, respectively). Extract and diclofenac also significantly (F

3, 24

=19.38

P

<0.0001; F

3, 24

=59.89

P

<0.0001, respectively) minimized progression of inflammation from acute to chronic phase. Extract produced a maximal effect of 83% at 400 mg/kg at chronic phase. Diclofenac also had maximal effect of 98% at 30 and 100 mg/kg. Extract and diclofenac, significantly (F

4, 12

=5.09

P

<0.05; F

4, 12

=31.98

P

<0.001, respectively) reduced arthritic score.

Conclusion:

This study shows methanolic extracts of

Napoleona imperialis

leaves have anti-inflammaory effects.

Pages

89

Last Page

95

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