•  
  •  
 

Abstract

Introduction:

UTI causes significant child morbidity and mortality.

Enterobacteriaecae

are most common uropathogens. Recently

Enterococcus spp

, yeast and

Staphylococcus aureus

have emerged as paediatric uropathogens. Understanding of local susceptibility pattern guides antibiotic therapy in UTI. This study describes demographic and susceptibility profile of uropathogens in children.

Method:

The urinary isolates were analysed retrospectively and data on age, sex, result of urine culture, etiological agent and susceptibility pattern were obtained from laboratory record books.

Result:

315 urine samples analysed showed 34% significant bacteruria. Prevalence of UTI among male and female children was 62% and 37.9% respectively, statistically significant (

P

= .0329). Predominant uropathogens were

Klebsiella spp.

(66.6%),

Escherichia coli

(25.9%),

Candida albicans

(20.3%) and

Enterococcus spp

(15.7%). Bacteruria with pyuria was 26.03%. Sterile pyuria present in 9.52% of cases. A statistically significant correlation between

Pseudomonas

and pyuria was noted. Both

Klebsiella spp

and

E coli

were least susceptible to augmentin and cephalosporins (25%) and most susceptible to carbapenems. Proteus spp was most susceptible to aminoglycosides (75%) and

Acinetobacter spp

to Piperacillin-tazobactam (83.3%) while

Pseudomonas

to carbapenem (75%).

Acinetobacter

was most resistant with 100% resistance to augmentin, cephalosporins, aminoglycosides, fluoroquinolones and nitrofurantoin. All GNRs were 100% resistant to nitrofurantoin except

E coli

(39.2%) and

Klebsiella spp

(41.6%) susceptible.

Enterococcus

were 100% sensitive while 87.5% of

Staphylococcus aureus

were sensitive to teicoplanin and linezolid.

Conclusion:

Ongoing monitoring should note any changes in paediatric uropathogens and their antibiotic resistance pattern to guide the clinicians for proper empirical management of UTI in children.

Pages

137

Last Page

141

Download

Share

COinS