Assessment of antidiabetic potential of

Authors

Thakur Rakesh Singh, Department of Rasa Shastra and Bhaishajya Kalpana, Government Ayurved College, Raipur, Chhattisgarh, India
Laxmi Narayan Gupta, Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Indi
Neeraj Kumar, Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, Indi
Vikas Kumar, Department of Pharmaceutics, Neuropharmacology Research Laboratory, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, Indi

Abstract

Objectives:

To assess the antidiabetic potential of

Shilajatvadi Lauha

(SL) processed with

Daruharidra

(modified SL [MSL]) in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats.

Materials and Methods:

Animals were divided into diabetic and nondiabetic groups. Type 2 diabetes in rats was induced with a single dose of STZ (65 mg/kg) NA (110 mg/kg) intraperitoneal diabetic rats were treated with formulation MSL (10, 30, and 100 mg/kg) and glibenclamide (10 mg/kg) once daily for 14 days orally. After 14 days treatment, fasting blood glucose and plasma insulin were assayed. Different biochemical parameters such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and very LDL-C (VLDL-C) were also examined.

Results:

MSL significantly lowered the blood glucose and increases insulin level, which was comparable to the standard antidiabetic drug, glibenclamide. Treatment with MSL showed a significantly reduction in the levels of TC, TG, LDL-C, and VLDL-C and increases the level of HDL-C.

Conclusion:

MSL possess significant antidiabetic and antihyperlipidemic activity in Type 2 diabetes mellitus rats. The results are encouraging and further studies can be used to evaluate the exact mechanism of action to develop a novel molecule that will benefit the ailing.

Recommended Citation

Singh, Thakur Rakesh; Gupta, Laxmi Narayan; Kumar, Neeraj; and Kumar, Vikas (2016) "Assessment of antidiabetic potential of," Indian Journal of Health Sciences and Biomedical Research KLEU: Vol. 9: Iss. 3, Article 13.
DOI: https://doi.org/10.4103/2349-5006.196334
Available at: https://kleijhsbr.researchcommons.org/journal/vol9/iss3/13

Pages

308

Last Page

314

Copyright

© 2016 Indian Journal of Health Sciences and Biomedical Research KLEU | Published by Wolters Kluwer – Medknow